Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299161 | 0.91 | LMNA (0.71) | LMNAALDH1A1NPSR1NR3C2NR3C1 | |
| SCHEMBL7302805 | 0.91 | LMNA (0.71) | LMNAALDH1A1NPSR1NR3C2NR3C1 | |
| SCHEMBL7299169 | 0.89 | LMNA (0.58) | LMNANR3C2NR3C1PGRL3MBTL1 | |
| SCHEMBL8548928 | 0.88 | LMNA (0.60) | LMNAALDH1A1NPSR1NR3C2NR3C1 | |
| SCHEMBL7298261 | 0.88 | LMNA (0.58) | LMNANR3C2NR3C1PGRPOLB | |
| SCHEMBL7301526 | 0.86 | LMNA (0.62) | LMNAALDH1A1NPSR1NR3C2NR3C1 | |
| SCHEMBL7302522 | 0.85 | LMNA (0.54) | LMNANR3C2NR3C1PGRL3MBTL1 | |
| SCHEMBL7300845 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1POLBMEN1 | |
| SCHEMBL7305178 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1PGRL3MBTL1 | |
| SCHEMBL8543754 | 0.80 | LMNA (0.64) | LMNAALDH1A1NPSR1NR3C2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | disclosed |
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| CN-1109880-A | 3-(2-aminoethyl)-4-[3-(trifluoromethyl) benzoyl]-3,4-dihydro-1,4-benzoxazine derivative and preparation of same | SYNTHELABO (FR) | 1995-10-11 | — | — | CN | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| EP-0666260-A1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |
| CN-1099032-A | Benzoxazine derivatives, their preparation and their use in medicine | SYNTHELABO (FR) | 1995-02-22 | — | — | CN | disclosed |
| EP-0614893-A1 | Benzoazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |