Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298258 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MAPTNPSR1TSHRCYP1A2 | |
| SCHEMBL12591107 | 0.74 | CES2 (0.45) | ALDH1A1MAPTTSHRLMNARAB9A | |
| SCHEMBL7298648 | 0.72 | ALDH1A1 (0.44) | ALDH1A1MAPTTSHRLMNARAB9A | |
| SCHEMBL7298652 | 0.72 | ALDH1A1 (0.44) | ALDH1A1MAPTTSHRLMNARAB9A | |
| SCHEMBL19980208 | 0.68 | ALDH1A1 (0.40) | ALDH1A1MAPTTSHRHIF1ATDP1 | |
| SCHEMBL19980206 | 0.67 | TSHR (0.41) | ALDH1A1MAPTTSHRLMNARAB9A | |
| SCHEMBL7291203 | 0.66 | MAPT (0.61) | ALDH1A1MAPTNPSR1TSHRCYP1A2 | |
| SCHEMBL23188930 | 0.66 | TSHR (0.46) | ALDH1A1MAPTTSHRCYP1A2LMNA | |
| SCHEMBL21157019 | 0.66 | ALDH1A1 (0.38) | ALDH1A1MAPTTSHRHIF1ATDP1 | |
| SCHEMBL12591127 | 0.65 | RAB9A (0.39) | ALDH1A1MAPTTSHRLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | claimed |
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | disclosed |