Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298128 | 0.85 | MAP3K14 (0.42) | MAP3K14AHRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9584128 | 0.77 | ALDH1A1 (0.44) | PIK3CAPIK3CBPIK3CGNPC1RAB9A | |
| SCHEMBL9585550 | 0.77 | FABP6 (0.40) | PIK3CAPIK3CBPIK3CGMAOBNPC1 | |
| SCHEMBL7291678 | 0.77 | MAPT (0.48) | AHRPIK3CAPIK3CBPIK3CGMAOB | |
| SCHEMBL577551 | 0.77 | FABP6 (0.40) | PIK3CAPIK3CBPIK3CGMAOBNPC1 | |
| SCHEMBL578279 | 0.74 | RAB9A (0.41) | NPC1RAB9A | |
| SCHEMBL9586832 | 0.74 | RAB9A (0.41) | NPC1RAB9A | |
| SCHEMBL7289620 | 0.73 | PKM (0.38) | MAOBNPC1RAB9A | |
| SCHEMBL7297788 | 0.73 | MAPT (0.38) | PIK3CAPIK3CBPIK3CGNPC1RAB9A | |
| SCHEMBL1492679 | 0.73 | PARP1 (0.40) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |