Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307885 | 0.87 | PLA2G2A (0.36) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL7304792 | 0.84 | MMP1 (0.60) | MMP1MMP13ALDH1A1 | |
| SCHEMBL7303599 | 0.77 | MMP1 (0.49) | MMP1HDAC8HDAC1MMP13ALDH1A1 | |
| SCHEMBL7308395 | 0.76 | MMP1 (0.48) | MMP1MMP13 | |
| SCHEMBL7301981 | 0.76 | MMP1 (0.61) | MMP1MMP13 | |
| SCHEMBL7311267 | 0.75 | MMP1 (0.73) | MMP1HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL7306362 | 0.72 | MMP1 (0.49) | MMP1MEN1KMT2AMMP13ALDH1A1 | |
| SCHEMBL7305353 | 0.72 | MMP1 (0.48) | MMP1MEN1KMT2AMMP13ALDH1A1 | |
| SCHEMBL7298947 | 0.71 | MMP1 (0.47) | MMP1KMT2AMMP13ALDH1A1HTT | |
| SCHEMBL7311858 | 0.71 | MMP1 (0.45) | MMP1MMP13ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |