Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.49 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RNF4 | P78317 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305353 | 0.99 | MMP1 (0.48) | MMP1MMP2MMP13MMP14ADAMTS4 | |
| SCHEMBL7304792 | 0.89 | MMP1 (0.60) | MMP1MMP2MMP13MMP14ADAMTS4 | |
| SCHEMBL7303726 | 0.87 | ALDH1A1 (0.44) | MMP1ALDH1A1MAPTRNF4MEN1 | |
| SCHEMBL7307399 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MAPTRNF4MEN1GLA | |
| SCHEMBL7299168 | 0.84 | LMNA (0.39) | MMP1MMP2MMP13ALDH1A1MAPT | |
| SCHEMBL7305235 | 0.84 | MMP1 (0.47) | MMP1MMP2MMP14MMP9MMP12 | |
| SCHEMBL7309991 | 0.83 | LMNA (0.41) | MMP1MMP2MMP13ALDH1A1MAPT | |
| SCHEMBL7303599 | 0.79 | MMP1 (0.49) | MMP1MMP2MMP13MMP14ALDH1A1 | |
| SCHEMBL7301981 | 0.78 | MMP1 (0.61) | MMP1MMP2MMP13MMP14MMP9 | |
| SCHEMBL7305971 | 0.78 | MMP1 (0.40) | MMP1MMP2MMP13MMP14MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |