Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290451 | 0.91 | CCNC (0.38) | CCNCCDK8HASPINCDK19KDM4E | |
| SCHEMBL7294108 | 0.78 | CA12 (0.40) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL7373569 | 0.78 | CCNC (0.32) | CCNCCDK8HASPINCDK19CDC25B | |
| SCHEMBL7291851 | 0.77 | MAPK14 (0.31) | SMN1; SMN2CDC25BMAPK14 | |
| SCHEMBL7300176 | 0.77 | NPC1 (0.32) | CDC25B | |
| SCHEMBL7376043 | 0.76 | CYP11B2 (0.33) | CCNCCDK8HASPINCDK19CYP11B1 | |
| SCHEMBL8088432 | 0.76 | PDE4A (0.43) | — | |
| SCHEMBL8084294 | 0.76 | ALDH1A1 (0.37) | ALDH1A1MAPK14MEN1KMT2A | |
| SCHEMBL7314077 | 0.75 | FGFR1 (0.32) | CCNCCDK8HASPINCDK19CYP11B1 | |
| SCHEMBL7300440 | 0.75 | CCNC (0.32) | CCNCCDK8HASPINCDK19MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |
| EP-0308792-A2 | Azachromane derivatives | MERCK PATENT GmbH (DE) | 1989-03-29 | — | — | EP | disclosed |