Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585033 | 0.74 | TDP1 (0.37) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7299445 | 0.70 | ESPL1 (0.40) | TDP1TSHRPOLBGAAMEN1 | |
| SCHEMBL7300502 | 0.67 | TSHR (0.37) | TSHRSMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL7290303 | 0.67 | TDP1 (0.41) | TDP1TSHRSMN1; SMN2GPR35POLB | |
| SCHEMBL376449 | 0.61 | ALDH1A1 (0.46) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7298186 | 0.61 | MAPT (0.42) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL8361517 | 0.60 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7297060 | 0.60 | TDP1 (0.40) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| Ethane SCHEMBL28101016 | 0.60 | TDP1 (0.52) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| Butane SCHEMBL27519037 | 0.60 | HSD17B10 (0.60) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |