Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561072 | 0.77 | ALDH1A1 (0.47) | ALDH1A1ELANEKMT2ATSHRKDM4E | |
| SCHEMBL7288793 | 0.73 | ALDH1A1 (0.61) | ALDH1A1HTTL3MBTL1ELANEMAPT | |
| SCHEMBL7414653 | 0.72 | ALDH1A1 (0.60) | ALDH1A1HTTL3MBTL1ELANEMAPT | |
| SCHEMBL5043169 | 0.69 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HPGDNPSR1L3MBTL1 | |
| SCHEMBL8564952 | 0.69 | ALDH1A1 (0.61) | ALDH1A1HPGDHTTL3MBTL1ELANE | |
| SCHEMBL11186403 | 0.68 | KMT2A (0.56) | ALDH1A1NPSR1HTTMAPTKMT2A | |
| SCHEMBL6689255 | 0.68 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDNPSR1KMT2A | |
| SCHEMBL16370936 | 0.63 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HPGDHTTAVPR1A | |
| SCHEMBL7532980 | 0.63 | KDM4E (0.54) | ALDH1A1SMN1; SMN2HTTL3MBTL1ELANE | |
| SCHEMBL7509476 | 0.63 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |