Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300094 | 1.00 | CTRC (0.49) | CTRCCETPALDH1A1CYP3A4TSHR | |
| SCHEMBL7022120 | 0.95 | ALDH1A1 (0.44) | CTRCCETPALDH1A1CYP3A4TSHR | |
| SCHEMBL8055631 | 0.90 | CA1 (0.44) | CTRCALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL7300652 | 0.87 | ALDH1A1 (0.40) | CTRCALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL9773229 | 0.84 | TSHR (0.42) | CTRCALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL9773189 | 0.84 | TSHR (0.42) | CTRCALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL9773184 | 0.84 | TSHR (0.42) | CTRCALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL9773226 | 0.84 | TSHR (0.42) | CTRCALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL7375987 | 0.84 | BLM (0.41) | ALDH1A1MAPK1TDP1L3MBTL1MEN1 | |
| SCHEMBL5012826 | 0.84 | BLM (0.41) | ALDH1A1MAPK1TDP1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |