Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022120 | 0.89 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1CA2CA1 | |
| SCHEMBL7300090 | 0.87 | CTRC (0.49) | ALDH1A1KMT2AMEN1TDP1MAPK1 | |
| SCHEMBL7300094 | 0.87 | CTRC (0.49) | ALDH1A1KMT2AMEN1TDP1MAPK1 | |
| SCHEMBL8055631 | 0.86 | CA1 (0.44) | ALDH1A1KMT2AMEN1CA2CA12 | |
| SCHEMBL7313485 | 0.86 | CTSK (0.43) | ALDH1A1CTSKCTSB | |
| SCHEMBL5870158 | 0.86 | CTSK (0.43) | ALDH1A1CTSKCTSB | |
| SCHEMBL7375987 | 0.85 | BLM (0.41) | ALDH1A1KMT2AMEN1CA2CA12 | |
| SCHEMBL7344531 | 0.85 | BLM (0.41) | ALDH1A1KMT2AMEN1CA2CA12 | |
| SCHEMBL15627203 | 0.85 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1CA2CA12 | |
| SCHEMBL5012826 | 0.85 | BLM (0.41) | ALDH1A1KMT2AMEN1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |