Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115250 | 0.77 | HTR2C (0.41) | CA12CA1CA9CA2HTR2C | |
| SCHEMBL7371700 | 0.74 | HIF1A (0.41) | CA12CA1CA9CA2HIF1A | |
| SCHEMBL1748567 | 0.72 | HTR2C (0.49) | CA12CA1CA9HIF1AEPAS1 | |
| SCHEMBL29644871 | 0.72 | HTR2C (0.49) | CA12CA1CA9HIF1AEPAS1 | |
| Ethane SCHEMBL10720474 | 0.71 | HTR2C (0.47) | CA12CA1CA9HIF1AEPAS1 | |
| SCHEMBL8120470 | 0.70 | MAPT (0.44) | HIF1AEPAS1NPC1EP300MAPT | |
| SCHEMBL8911274 | 0.70 | CA12 (0.37) | CA12CA1CA9CA2NPC1 | |
| SCHEMBL30237273 | 0.70 | CA12 (0.33) | CA12CA1CA9CA2 | |
| SCHEMBL1115233 | 0.69 | HTR2C (0.40) | CA12CA1CA9CA2MEN1 | |
| SCHEMBL2011575 | 0.69 | HIF1A (0.48) | CA12CA1CA9HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |
| EP-0308792-A2 | Azachromane derivatives | MERCK PATENT GmbH (DE) | 1989-03-29 | — | — | EP | disclosed |