Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337401 | 0.95 | GPR84 (0.46) | HCAR2GPR84MAPK1CYP1A2CASP1 | |
| SCHEMBL7914214 | 0.90 | PARP1 (0.40) | HCAR2PARP1GPR84MAPK1PIN1 | |
| SCHEMBL651 | 0.89 | PIN1 (0.42) | HCAR2MAPK1CYP1A2CASP1CYP2C19 | |
| SCHEMBL29109938 | 0.86 | LMNA (0.42) | HCAR2PARP1GPR84MAPK1CYP1A2 | |
| SCHEMBL2804373 | 0.82 | PIN1 (0.44) | HCAR2MAPK1CYP1A2CASP1CYP2C19 | |
| SCHEMBL27374288 | 0.81 | HCAR2 (0.43) | HCAR2PARP1GPR84MAPK1ALDH1A1 | |
| SCHEMBL3038066 | 0.81 | PARP1 (0.41) | HCAR2PARP1GPR84MAPK1ALDH1A1 | |
| SCHEMBL27322051 | 0.80 | PARP1 (0.40) | HCAR2PARP1GPR84MAPK1ALDH1A1 | |
| SCHEMBL27336187 | 0.79 | PIN1 (0.38) | HCAR2GPR84MAPK1CYP1A2CASP1 | |
| SCHEMBL3839556 | 0.79 | PARP1 (0.39) | HCAR2PARP1GPR84MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117098761-A | Imidazo [4,5-d ] pyridazine derivatives, preparation thereof and therapeutic use thereof | 赛诺菲 | 2023-11-21 | — | — | CN | disclosed |
| CN-1101384-C | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 2003-02-12 | — | — | CN | disclosed |
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| EP-0545912-B1 | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| US-6005105-A | Process for producing imidazole derivative | PHARMACIA & UPJOHN COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| CN-1189490-A | Process for preparing 1-biphenylmethylimidazole derivatives | SANKYO CO (JP) | 1998-08-05 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0705266-B1 | PROCESS FOR PRODUCING IMIDAZOLE DERIVATIVE | UPJOHN CO (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0609289-B1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UPJOHN CO (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5281615-A | Hypotensive agents | G. D. SEARLE & CO. (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0545912-A2 | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1993-06-09 | — | — | EP | disclosed |
| EP-0540209-A1 | Imidazole derivatives and pharmaceutical compositions containing the same | THE UPJOHN COMPANY (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008193-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |
| CN-1065063-A | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1992-10-07 | — | — | CN | disclosed |
| EP-0503785-A1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-09-16 | — | — | EP | disclosed |
| US-5104891-A | CYCLOHEPTIMIDAZOLONE COMPOUNDS AS ANGIOTENSIN II ANTAGONISTS FOR CONTROL OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1992-04-14 | — | — | US | disclosed |
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |
| EP-0432737-A1 | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension | G.D. Searle & Co. (US) | 1991-06-19 | — | — | EP | disclosed |