Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296366 | 0.87 | LTA4H (0.48) | TSHRKDM4ESIGMAR1LIPE | |
| SCHEMBL22936210 | 0.86 | ALDH1A1 (0.52) | TSHRKDM4EALDH1A1NPC1SIGMAR1 | |
| SCHEMBL7298308 | 0.85 | TSHR (0.50) | TSHRKDM4ESIGMAR1ACHE | |
| SCHEMBL7307983 | 0.84 | MEN1 (0.51) | TSHRKDM4EALDH1A1SIGMAR1KCNH2 | |
| SCHEMBL8342490 | 0.83 | KDM4E (0.47) | TSHRKDM4EALDH1A1SIGMAR1HTT | |
| SCHEMBL29495264 | 0.81 | ALDH1A1 (0.52) | TSHRKDM4EALDH1A1NPC1SIGMAR1 | |
| SCHEMBL28722474 | 0.81 | ALDH1A1 (0.52) | TSHRKDM4EALDH1A1NPC1SIGMAR1 | |
| SCHEMBL31352326 | 0.77 | MEN1 (0.59) | TSHRKDM4EALDH1A1NPC1SIGMAR1 | |
| SCHEMBL7298695 | 0.76 | NPC1 (0.47) | TSHRKDM4EALDH1A1NPC1SIGMAR1 | |
| SCHEMBL7295963 | 0.75 | ALDH1A1 (0.49) | TSHRKDM4EALDH1A1NPC1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| US-5856349-A | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5652254-A | TREATMENT OF DEGENERATIVE DISEASES, RHEUMATOID ARTHRITIS, PSORIASIS, CYSTIC FIBROSIS | SANOFI, S.A. (FR) | 1997-07-29 | — | — | US | disclosed |
| US-5563163-A | TREATMENT OF DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5488062-A | 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5376653-A | A protease enzyme inhibitor for treating degenerative diseases , respiratory system disorders, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |