SCHEMBL7300809

SCHEMBL7300809

[c]1ccc(Oc2ccc(-c3ccsc3)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.45
CYP2B6 P20813 3/20 0.45
CYP2E1 P05181 2/20 0.45
LTA4H P09960 3/20 0.45
KCNH2 Q12809 1/20 0.39
CYP17A1 P05093 1/20 0.39
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
LPL P06858 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
HRH2 P25021 1/20 0.35
HRH1 P35367 1/20 0.35
TNK2 Q07912 1/20 0.35
PDGFRB P09619 2/20 0.35
PDGFRA P16234 2/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDR P35968 1/20 0.33
CHEK2 O96017 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL196071 0.82 CYP2A6 (0.58) CYP2A6CYP2B6CYP2E1KCNH2CYP17A1
SCHEMBL10839908 0.82 ALDH1A1 (0.39) LTA4HCYP3A4
SCHEMBL6056745 0.81 CYP2A6 (0.65) CYP2A6CYP2B6CYP2E1LTA4HKCNH2
SCHEMBL7247515 0.80 MMP1 (0.30)
SCHEMBL14465263 0.79 ALDH1A1 (0.54) CYP2A6CYP2B6CYP2E1LTA4HKCNH2
SCHEMBL14542299 0.79 ESR2 (0.54) CYP2A6CYP2B6CYP2E1LTA4HKCNH2
SCHEMBL7300800 0.76 CYP2A6 (0.48) CYP2A6CYP2B6CYP2E1LTA4HKCNH2
SCHEMBL4613525 0.76 CYP2A6 (0.47) CYP2A6CYP2B6CYP2E1KCNH2CYP17A1
SCHEMBL4310665 0.75 LTA4H (0.52) CYP2A6CYP2B6CYP2E1LTA4HKCNH2
SCHEMBL27989815 0.74 CYP2A6 (0.74) CYP2A6CYP2B6CYP2E1KCNH2CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1177821-C Matrix metalloprotease inhibitors - 2004-12-01 CN claimed
EP-0780386-B1 Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 2002-10-02 EP claimed
US-5932595-A ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT SYNTEX (U.S.A.) INC. (US) 1999-08-03 US claimed
CN-1160045-A Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 1997-09-24 CN claimed
EP-0780386-A1 Matrix metalloprotease inhibitors F. HOFFMANN-LA ROCHE AG (CH) 1997-06-25 EP claimed
CN-1177821-C Matrix metalloprotease inhibitors - 2004-12-01 CN disclosed
EP-0780386-B1 Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5932595-A ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT SYNTEX (U.S.A.) INC. (US) 1999-08-03 US disclosed
CN-1160045-A Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 1997-09-24 CN disclosed
EP-0780386-A1 Matrix metalloprotease inhibitors F. HOFFMANN-LA ROCHE AG (CH) 1997-06-25 EP disclosed