Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301238 | 0.90 | RAB9A (0.54) | LMNATP53HSD17B10ALDH1A1NPC1 | |
| SCHEMBL1340139 | 0.82 | SMN1; SMN2 (0.70) | LMNATP53ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL27751166 | 0.82 | LMNA (0.69) | LMNATP53HSD17B10ALDH1A1NPC1 | |
| SCHEMBL1341401 | 0.80 | SMN1; SMN2 (0.70) | LMNATP53ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL7308749 | 0.79 | LMNA (0.64) | LMNATP53HSD17B10ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7304548 | 0.78 | LMNA (0.62) | LMNATP53HSD17B10ALDH1A1NPC1 | |
| SCHEMBL2753912 | 0.78 | LMNA (0.69) | LMNATP53HSD17B10ALDH1A1NPC1 | |
| SCHEMBL6220893 | 0.77 | MAPT (0.74) | LMNATP53ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL7930533 | 0.77 | GAA (0.77) | LMNATP53ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL11368738 | 0.76 | SMN1; SMN2 (0.72) | LMNATP53ALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |