Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300895 | 0.90 | LMNA (0.66) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL10349418 | 0.80 | TP53 (0.56) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL20392523 | 0.79 | RAB9A (0.59) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL234083 | 0.76 | PDE5A (0.57) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL4968797 | 0.76 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL2390027 | 0.75 | PDE5A (0.72) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL2786880 | 0.74 | TP53 (0.59) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL1136836 | 0.73 | KDM4E (0.66) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL7299471 | 0.73 | MME (0.52) | RAB9ASMN1; SMN2TP53NPC1POLB | |
| SCHEMBL6878797 | 0.72 | ALDH1A1 (0.62) | RAB9ASMN1; SMN2TP53NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |