Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.56 |
| ▸ | MMP1 | P03956 | 7/20 | 0.56 |
| ▸ | MMP3 | P08254 | 6/20 | 0.56 |
| ▸ | PDE4A | P27815 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | MMP13 | P45452 | 4/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP7 | P09237 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CPA3 | P15088 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311143 | 0.83 | MMP1 (0.54) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7311140 | 0.83 | MMP1 (0.54) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7313243 | 0.83 | MMP2 (0.51) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7073256 | 0.82 | MMP2 (0.77) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL27477106 | 0.78 | PPARG (0.52) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7299010 | 0.78 | MMP1 (0.76) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7302153 | 0.76 | MMP2 (0.73) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL27611646 | 0.74 | CPA1 (0.58) | CPA1CPB1CPA3CPB2MEN1 | |
| SCHEMBL7310358 | 0.74 | MMP1 (0.70) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7310353 | 0.74 | MMP1 (0.70) | MMP2MMP1MMP3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1177821-C | Matrix metalloprotease inhibitors | - | 2004-12-01 | — | — | CN | disclosed |
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| CN-1160045-A | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 1997-09-24 | — | — | CN | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |