Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.77 |
| ▸ | MMP1 | P03956 | 9/20 | 0.77 |
| ▸ | MMP3 | P08254 | 8/20 | 0.77 |
| ▸ | PDE4A | P27815 | 8/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.77 |
| ▸ | MMP13 | P45452 | 2/20 | 0.68 |
| ▸ | MMP9 | P14780 | 3/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824624 | 0.87 | MMP2 (1.00) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7692016 | 0.86 | MMP1 (0.69) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7207040 | 0.84 | MMP1 (0.76) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7305191 | 0.83 | MMP1 (0.76) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7301198 | 0.82 | MMP2 (0.56) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7212123 | 0.81 | MMP1 (1.00) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL6823613 | 0.81 | MMP2 (0.87) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL6823424 | 0.81 | MMP1 (0.87) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL6825866 | 0.81 | MMP2 (0.85) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL6933282 | 0.81 | MMP1 (0.76) | MMP2MMP1MMP3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030207889-A1 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity | OWEN DAVID ALAN (GB) | 2003-11-06 | — | — | US | disclosed |
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |
| US-6118001-A | ANTICANCER AGENT; ANTIARTHRITIC AGENT | DARWIN DISCOVERY, LTD. (GB) | 2000-09-12 | — | — | US | disclosed |
| EP-0968182-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998005635-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1998-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207889-A1 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity | MMP13, MMP2, MMP9 | MMP2 2/4885MMP1 16/4885MMP3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.