Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | CDC25A | P30304 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303767 | 0.75 | TSHR (1.00) | TSHRALDH1A1HSD17B10HPGDKMT2A | |
| SCHEMBL7305823 | 0.74 | TSHR (0.76) | TSHRALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL13308598 | 0.73 | HSD17B10 (0.45) | TSHRALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL1491086 | 0.72 | CMA1 (0.56) | TSHRALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL3077245 | 0.71 | SMN1; SMN2 (0.47) | TSHRALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL7311114 | 0.71 | TSHR (0.75) | TSHRALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL22639937 | 0.71 | QPCT (0.50) | TSHRCDC25ACDC25BALDH1A1LMNA | |
| SCHEMBL7302490 | 0.67 | TSHR (0.59) | TSHRALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL7297521 | 0.66 | TSHR (0.67) | TSHRALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL28330025 | 0.66 | TSHR (0.64) | TSHRLMNAHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636626-A1 | Pyrazolopyrimidine Derivatives | LABORATOIRES GLAXO SA (FR) | 1995-02-01 | — | — | EP | disclosed |