Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272751 | 0.85 | ALDH1A1 (0.56) | MMEALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7265100 | 0.85 | ALDH1A1 (0.56) | MMEALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7296774 | 0.84 | MME (0.44) | MMECTSSCTSKPSMB5 | |
| SCHEMBL7344601 | 0.83 | MME (0.41) | MMEOPRM1OPRK1OPRD1CTSS | |
| SCHEMBL7307301 | 0.78 | CYP2C19 (0.51) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL8882780 | 0.77 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL8787955 | 0.76 | ALDH1A1 (0.47) | MMEALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL11360473 | 0.75 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL8106811 | 0.74 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL8787182 | 0.74 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657453-B1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL MYERS SQUIBB CO (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5637698-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITOR | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5525723-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0657453-A1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |