Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | ABAT | P80404 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984572 | 0.84 | SPHK2 (0.42) | MAPTHPGDKDM4EHIF1ASLC22A6 | |
| SCHEMBL28900428 | 0.83 | ACE (0.47) | MMEACE | |
| SCHEMBL1900364 | 0.82 | KMT2A (0.54) | KMT2AHPGD | |
| SCHEMBL9771647 | 0.80 | ATM (0.54) | KMT2AMAPK1MEN1HIF1A | |
| SCHEMBL97054 | 0.80 | KMT2A (0.43) | ALDH1A1MAPTKMT2AHPGDHSD17B10 | |
| SCHEMBL7579636 | 0.79 | RAB9A (0.55) | ALDH1A1HPGD | |
| SCHEMBL1416028 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MAPTKMT2AHPGDMEN1 | |
| SCHEMBL28159346 | 0.78 | PTPRC (0.49) | MAPTPTPRCTDP1 | |
| SCHEMBL28037255 | 0.77 | MAOB (0.45) | KMT2AHSD17B10MEN1BLMKDM4E | |
| SCHEMBL3982704 | 0.77 | TSHR (0.46) | ALDH1A1KMT2AHPGDKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014200885-A1 | PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-18 | — | — | WO | claimed |
| US-5998410-A | Sulfonamide derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| US-5795890-A | ELASTASE INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-08-18 | — | — | US | disclosed |
| EP-0769498-A1 | Sulfonamide derivatives with elastase inhibiting activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-04-23 | — | — | EP | disclosed |