Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.87 |
| ▸ | FPR2 | P25090 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292760 | 0.92 | KMT2A (0.73) | KMT2AFPR2SIGMAR1POLBTSHR | |
| SCHEMBL17117383 | 0.82 | FPR2 (0.71) | KMT2AFPR2LMNAALDH1A1GAA | |
| SCHEMBL6244424 | 0.81 | KMT2A (0.58) | KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL16562082 | 0.80 | EPHX2 (0.76) | KMT2AFPR2LMNAALDH1A1EPHX2 | |
| SCHEMBL17117215 | 0.80 | EPHX2 (0.76) | KMT2AFPR2LMNAALDH1A1EPHX2 | |
| SCHEMBL6121330 | 0.80 | LMNA (0.74) | KMT2ALMNAALDH1A1GAAPOLB | |
| SCHEMBL6374706 | 0.79 | FPR2 (1.00) | KMT2AFPR2ALDH1A1ALOX15 | |
| SCHEMBL6379203 | 0.79 | FPR2 (1.00) | KMT2AFPR2ALDH1A1ALOX15 | |
| SCHEMBL6374699 | 0.79 | FPR2 (1.00) | KMT2AFPR2ALDH1A1ALOX15 | |
| SCHEMBL5189503 | 0.79 | FPR2 (0.68) | KMT2AFPR2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |