Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 10/20 | 0.44 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MMP3 | P08254 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | FCER2 | P06734 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295712 | 0.84 | REN (0.49) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7442704 | 0.80 | TSHR (0.50) | HDAC1HDAC8 | |
| SCHEMBL17553593 | 0.77 | REN (0.53) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7293025 | 0.75 | MMP8 (0.55) | MMP2MMP1MMP3FCER2MMP7 | |
| SCHEMBL7294611 | 0.75 | BIRC2 (0.48) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7301616 | 0.75 | REN (0.48) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7293701 | 0.75 | REN (0.48) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7287606 | 0.75 | CYP1A2 (0.56) | HDAC1MME | |
| SCHEMBL7270032 | 0.75 | CYP1A2 (0.56) | HDAC1MME | |
| SCHEMBL6448843 | 0.74 | TSHR (0.47) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |