Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 14/20 | 0.47 |
| ▸ | MMP1 | P03956 | 9/20 | 0.47 |
| ▸ | MMP3 | P08254 | 9/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 4/20 | 0.45 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443866 | 0.91 | MME (0.55) | RENMMP2MMP1MMP3MME | |
| SCHEMBL6443858 | 0.91 | MME (0.55) | RENMMP2MMP1MMP3MME | |
| SCHEMBL7302834 | 0.89 | MMP2 (0.48) | MMP2MMP1MMP3MMP7BIRC2 | |
| SCHEMBL7378502 | 0.84 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9820278 | 0.81 | REN (0.46) | RENMMP2MMP1MMP3HDAC3 | |
| SCHEMBL7281516 | 0.79 | REN (0.47) | RENMMP1 | |
| SCHEMBL9556458 | 0.79 | REN (0.47) | RENMMP1 | |
| SCHEMBL7280399 | 0.79 | CYP1A2 (0.47) | — | |
| SCHEMBL17553593 | 0.78 | REN (0.53) | RENMMP2MMP1HDAC3HDAC4 | |
| SCHEMBL6443855 | 0.78 | MME (0.67) | RENMMP2MMEECE1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |