Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | OPA1 | O60313 | 1/20 | 0.36 |
| ▸ | EIF5B | O60841 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301624 | 1.00 | MTNR1A (0.40) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL7299112 | 0.77 | HTR3E (0.57) | MTNR1AMTNR1BHTR2AHTR2C | |
| Maleic Acid SCHEMBL7298744 | 0.76 | HTR3E (0.52) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| Fumaric Acid SCHEMBL7298751 | 0.76 | HTR3E (0.52) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL7332932 | 0.76 | MTNR1A (0.46) | MTNR1AMTNR1BHTR2AHTR2CHSD17B10 | |
| SCHEMBL2016131 | 0.76 | MTNR1A (0.48) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL2016130 | 0.76 | MTNR1A (0.48) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL9681702 | 0.75 | MTNR1A (0.41) | MTNR1AMTNR1BHTR2AHTR2COPA1 | |
| SCHEMBL13067746 | 0.75 | HTR2A (0.49) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL2020434 | 0.72 | MTNR1A (0.59) | MTNR1AMTNR1BHTR2AHTR2CMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026696-A | Psychotic disorders, anziety, nausea and vomiting | GLAXO GROUP LIMITED (GB) | 1991-06-25 | — | — | US | disclosed |
| US-4963546-A | Ketone derivatives which are antagonists of 5-HT at 5-HT3 receptors, compositions containing them, and method of use | GLAXO GROUP LIMITED (GB) | 1990-10-16 | — | — | US | disclosed |
| EP-0327307-A2 | Tricyclic ketone derivatives having a 5-HT3 antagonist activity | GLAXO GROUP LIMITED (GB) | 1989-08-09 | — | — | EP | disclosed |