Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | OPA1 | O60313 | 1/20 | 0.37 |
| ▸ | EIF5B | O60841 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.37 |
| ▸ | CD44 | P16070 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL7429503 | 0.94 | MTNR1A (0.37) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| SCHEMBL7299112 | 0.83 | HTR3E (0.57) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| SCHEMBL9730191 | 0.82 | HTR3A (0.37) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL7332932 | 0.82 | MTNR1A (0.46) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| Hydrochloric Acid SCHEMBL9730401 | 0.81 | HTR3A (0.38) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL9729932 | 0.80 | MCL1 (0.41) | HTR2AHTR2CCD44 | |
| Fumaric Acid SCHEMBL7298751 | 0.78 | HTR3E (0.52) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| Maleic Acid SCHEMBL7298744 | 0.78 | HTR3E (0.52) | MTNR1AMTNR1BHTR2AHTR2CHTR3E | |
| SCHEMBL8962729 | 0.77 | HTR3A (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7301618 | 0.75 | MTNR1A (0.40) | MTNR1AMTNR1BHTR2AHTR2COPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114950-A | Psychological disorders, anxiety, nausea and vomiting | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | claimed |
| JP-3128376-A | — | — | None | — | — | JP | disclosed |
| US-5114950-A | Psychological disorders, anxiety, nausea and vomiting | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| JP-H03128376-A | AMIDE DERIVATIVE | GLAXO GROUP LTD | 1991-05-31 | — | — | JP | disclosed |