Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258419 | 0.86 | PREP (0.39) | PREPCA12CA1CA9 | |
| SCHEMBL3280559 | 0.81 | LMNA (0.43) | LMNACA12CA1CA9AOC3 | |
| SCHEMBL10317188 | 0.81 | PREP (0.41) | PREPCA12CA1CA9ELANE | |
| SCHEMBL28344020 | 0.81 | ALDH1A1 (0.45) | LMNAPREPCA12CA1CA9 | |
| SCHEMBL14648955 | 0.81 | ALDH1A1 (0.45) | LMNAPREPCA12CA1CA9 | |
| SCHEMBL21405244 | 0.81 | PREP (0.42) | PREPCA12CA1CA9ELANE | |
| SCHEMBL1508160 | 0.80 | DRD2 (0.40) | LMNAPREPCA12CA1CA9 | |
| SCHEMBL1508406 | 0.79 | PREP (0.42) | LMNAPREPCA12CA1CA9 | |
| SCHEMBL20105057 | 0.78 | PREP (0.40) | PREPCA12CA1CA9ELANE | |
| SCHEMBL6763899 | 0.78 | PREP (0.53) | PREPCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550924-A1 | 2-Pyrrolidinone derivatives as HIV protease inhibitors | MERCK & CO. INC. (US) | 1993-07-14 | — | — | EP | disclosed |