Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9390635 | 0.87 | ANPEP (0.40) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL8374436 | 0.87 | ANPEP (0.40) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL9394697 | 0.87 | ANPEP (0.40) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL7566039 | 0.83 | ANPEP (0.37) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL11599296 | 0.83 | FOLH1 (0.38) | TPH1SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL27913200 | 0.81 | ANPEP (0.43) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL27913206 | 0.81 | ANPEP (0.43) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL5636527 | 0.80 | ALPI (0.40) | TPH1SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL2465468 | 0.78 | MMP2 (0.36) | — | |
| SCHEMBL6049152 | 0.77 | ANPEP (0.39) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1068586-C | Crystalline, polymorphic form of (S,S,S)-n-(1-[2-carboxy-3-(n2-mesyllysylamino)propyl]-1-cyclopenlylcarbonyl)tyrosine | PFIZER RES & DEV CO N V S A (IE) | 2001-07-18 | — | — | CN | disclosed |
| US-6180665-B1 | HYPOTENSIVE AGENTS; ANGIOTENSIN CONVERTING ENZYME INHIBITOR | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0731787-B1 | CRYSTALLINE, POLYMORPHIC FORM OF (S,S,S)-N-(1-[2-CARBOXY-3-(N2-MESYLLYSYLAMINO)PROPYL]-1-CYCLOPENTYLCARBONYL)TYROSINE | PFIZER LTD (GB) | 1999-01-13 | — | — | EP | disclosed |
| CN-1142816-A | Crystalline, polymorphic form of (S,S,S)-n-(1-[2-carboxy-3-(n2-mesyllysylamino)propyl]-1-cyclopenlylcarbonyl)tyrosine | PFIZER LTD (IE) | 1997-02-12 | — | — | CN | disclosed |
| CN-1031051-C | Cycloalkyl-substituted glutaramide antihypertensive agents | PFIZER (US) | 1996-02-21 | — | — | CN | disclosed |
| US-5362902-A | Diuretics and treatment of cardiovascular disorders | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| CN-1016778-B | spiro-substituted glutaric acid monoamides | PFIZER LTD (GB) | 1992-05-27 | — | — | CN | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5036104-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-4975444-A | INHIBITORS OF ANGIORENSIN-CONVERTING ENZYME AS WELL AS A ENDOPEPTIDASE; CARDIOTONIC AGENTS; GLAUCOMA; DIURETICS | PFIZER INC. (US) | 1990-12-04 | — | — | US | disclosed |
| US-4960792-A | HYPOTENSIVE AGENTS | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| WO-1990009374-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |
| CN-1040986-A | The preparation of the glutaramide derivatives of cycloalkyl substituted | PFIZER (US) | 1990-04-04 | — | — | CN | disclosed |
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |
| CN-87107371-A | The glutaramide diuretic agents of spiral shell-replacement | — | 1988-07-06 | — | — | CN | disclosed |