Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291933 | 0.90 | HTR4 (0.61) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7303858 | 0.87 | HTR4 (0.69) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7300888 | 0.83 | HTR4 (0.77) | CYP2C9PMP22NPSR1MEN1LMNA | |
| Hydrochloric Acid SCHEMBL7291228 | 0.82 | HTR4 (0.76) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL2940596 | 0.82 | CYP2C9 (0.94) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL29385613 | 0.82 | CYP2C9 (0.94) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7302574 | 0.81 | CYP2C9 (0.95) | CYP2C9PMP22NPSR1MEN1LMNA | |
| Hydrochloric Acid SCHEMBL7295175 | 0.81 | CYP2C9 (0.92) | CYP2C9PMP22NPSR1MEN1LMNA | |
| Maleic Acid SCHEMBL7302318 | 0.78 | CYP2C9 (0.86) | CYP2C9PMP22NPSR1MEN1LMNA | |
| Fumaric Acid SCHEMBL7302323 | 0.78 | CYP2C9 (0.86) | CYP2C9PMP22NPSR1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | claimed |
| WO-1993014745-A1 | USE OF 5-HT4 RECEPTOR ANTAGONISTS AS MEDICAMENTS FOR TREATING MIGRAINE | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | claimed |
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | disclosed |
| WO-1992014727-A1 | 3-PIPERIDINYLMETHYLCARBOXYLATE SUBSTITUTED INDOLES | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0501322-A1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LIMITED (GB) | 1992-09-02 | — | — | EP | disclosed |