Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291933 | 0.88 | HTR4 (0.61) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL7302280 | 0.87 | CYP2C9 (0.66) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL13036103 | 0.85 | HTR4 (0.54) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL13036127 | 0.83 | HTR4 (0.80) | HTR4CYP2C9PMP22CYP1A2CYP2D6 | |
| SCHEMBL7260342 | 0.83 | HTR4 (0.64) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL1502039 | 0.82 | HTR4 (1.00) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL29397805 | 0.82 | HTR4 (1.00) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL7300823 | 0.81 | CYP2C9 (0.74) | HTR4CYP2C9PMP22CYP1A2NPSR1 | |
| SCHEMBL3166017 | 0.81 | HTR4 (1.00) | HTR4CYP2C9PMP22CYP1A2CYP2D6 | |
| SCHEMBL7301492 | 0.79 | HTR4 (0.73) | HTR4CYP2C9CYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | disclosed |