Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475303 | 0.77 | CA1 (0.56) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL7303601 | 0.77 | CA1 (0.41) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL7302302 | 0.77 | CA1 (0.41) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL7302310 | 0.77 | CA1 (0.41) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL4658657 | 0.73 | SLC6A4 (0.50) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL28597945 | 0.72 | CA1 (0.46) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL4657002 | 0.72 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL9311330 | 0.70 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2L3MBTL1 | |
| SCHEMBL9309772 | 0.69 | SLC6A4 (0.50) | SLC6A4SLC6A3SLC6A2L3MBTL1 | |
| SCHEMBL8654796 | 0.69 | MITF (0.57) | SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |