Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.53 |
| ▸ | MMP1 | P03956 | 7/20 | 0.50 |
| ▸ | MMP2 | P08253 | 7/20 | 0.50 |
| ▸ | MMP3 | P08254 | 7/20 | 0.50 |
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302511 | 1.00 | SNCA (0.53) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL7301817 | 0.91 | SNCA (0.50) | SNCAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL7310693 | 0.89 | SNCA (0.48) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL7302523 | 0.87 | MMP1 (0.54) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL7309376 | 0.82 | CYP1A1 (0.49) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL6823210 | 0.81 | MMP1 (0.59) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7301821 | 0.77 | ALDH1A1 (0.48) | SNCAPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL7312057 | 0.77 | MMP2 (0.69) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL7310697 | 0.77 | SNCA (0.44) | SNCAMMP1MMP2MMP3PDE4A | |
| SCHEMBL7309205 | 0.76 | MMP2 (0.51) | SNCAMMP1MMP2MMP3PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |