Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.61 |
| ▸ | HTR3A | P46098 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302326 | 1.00 | HTR4 (0.61) | HTR4HTR3AHTR1AADRA2CACHE | |
| Hydrochloric Acid SCHEMBL7377307 | 0.99 | HTR4 (0.61) | HTR4HTR3AHTR1AADRA2CACHE | |
| Hydrochloric Acid SCHEMBL7377304 | 0.99 | HTR4 (0.61) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL7308214 | 0.96 | HTR4 (0.64) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL7308206 | 0.96 | HTR4 (0.64) | HTR4HTR3AHTR1AADRA2CACHE | |
| Hydrochloric Acid SCHEMBL7311562 | 0.95 | HTR4 (0.62) | HTR4HTR3AHTR1AADRA2CACHE | |
| Hydrochloric Acid SCHEMBL7311567 | 0.95 | HTR4 (0.62) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL7304699 | 0.83 | HTR4 (0.59) | HTR4HTR3AHTR1AADRA2CACHE | |
| Hydrochloric Acid SCHEMBL7311371 | 0.83 | HTR4 (0.58) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL7414248 | 0.79 | HTR3A (0.52) | HTR4HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0493031-B1 | Dihydrobenzofuran carboxamides and process for their preparation | PHARMACIA SPA (IT) | 1995-08-30 | — | — | EP | claimed |
| US-5362740-A | CNS, analgesics | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-11-08 | — | — | US | claimed |
| EP-0493031-A1 | Dihydrobenzofuran carboxamides and process for their preparation | PHARMACIA S.p.A. (IT) | 1992-07-01 | — | — | EP | claimed |