Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293745 | 0.81 | MAPT (0.42) | MAPK1HSD17B10MEN1KMT2AHTT | |
| SCHEMBL8321827 | 0.68 | ALOX5 (0.39) | MEN1KMT2ACA2GSK3BLMNA | |
| SCHEMBL12302829 | 0.63 | CLK4 (1.00) | CLK4DYRK1AMAPK1ALOX15TSHR | |
| 1,3-Dimethoxybenzene SCHEMBL9350 | 0.61 | ACHE (0.70) | CLK4DYRK1ACA2CES2CES1 | |
| 1,3-Dimethoxybenzene SCHEMBL901285 | 0.61 | ACHE (0.70) | CLK4DYRK1ACA2CES2CES1 | |
| 1,3-Dimethoxybenzene SCHEMBL27703685 | 0.60 | ACHE (0.61) | MEN1KMT2ACA2CES2CES1 | |
| 1,3-Dimethoxybenzene SCHEMBL7860661 | 0.59 | ACHE (0.67) | CLK4DYRK1ACA2CES2CES1 | |
| 1,3-Dimethoxybenzene SCHEMBL28343465 | 0.59 | ACHE (0.67) | CLK4DYRK1ACA2CES2CES1 | |
| 1,3-Dimethoxybenzene SCHEMBL15870025 | 0.59 | ACHE (0.67) | CA2CES2CES1LMNA | |
| 1,3-Dimethoxybenzene SCHEMBL28068595 | 0.59 | ACHE (0.67) | CLK4DYRK1ACA2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |