Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | ICMT | O60725 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 9/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9237227 | 0.86 | CDC25A (0.49) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL28666665 | 0.77 | DRD2 (0.44) | ICMTCNR2 | |
| SCHEMBL7136158 | 0.75 | HRH2 (0.49) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL7712112 | 0.72 | CNR2 (0.59) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL13131369 | 0.71 | CDC25A (0.72) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL8363931 | 0.71 | CDC25A (0.59) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL168724 | 0.71 | CDC25A (0.59) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL7712109 | 0.71 | CDC25A (0.56) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL14947367 | 0.71 | CDC25A (0.59) | CDC25AICMTCNR2CNR1 | |
| SCHEMBL4055511 | 0.71 | HRH2 (0.53) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734384-B1 | 3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2000-08-09 | — | — | EP | disclosed |
| EP-0939077-A2 | 3-Substituted 1-arylindole compounds as 5-HT2 antagonists | H. LUNDBECK A/S (DK) | 1999-09-01 | — | — | EP | disclosed |
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| US-5789404-A | CENTRAL NERVOUS SYSTEM DISORDERS AND ANTISEROTONIN AGENTS | H. LUNDBECK A/S (DK) | 1998-08-04 | — | — | US | disclosed |
| EP-0392959-B1 | Use of sertindole for the treatment of schizophrenia | LUNDBECK & CO AS H (DK) | 1997-08-20 | — | — | EP | disclosed |
| EP-0734384-A1 | 3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-10-02 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| US-5439922-A | Administering dopamine antagonists having reduced side effects | H. LUNDBECK A/S (DK) | 1995-08-08 | — | — | US | disclosed |
| WO-1993014758-A1 | USE OF 3-ARYLINDOLE AND 3-ARYLINDAZOLE DERIVATIVES FOR THE TREATMENT OF PSYCHOSES | H. LUNDBECK A/S (DK) | 1993-08-05 | — | — | WO | disclosed |
| WO-1993012790-A1 | USE OF ARYLINDOLE DERIVATIVES FOR THE TREATMENT OF PSYCHOSES | H. LUNDBECK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |
| EP-0533824-A1 | PIPERIDYL-SUBSTITUTED INDOLES. | LUNDBECK & CO AS H (DK) | 1993-03-31 | — | — | EP | disclosed |
| WO-1992015301-A1 | TREATMENT OF HYPERTENSION AND PERIPHERAL VASCULAR DISEASES | H. LUNDBECK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015302-A1 | TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | H. LUNDBECK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015303-A1 | TREATMENT OF COGNITIVE DISORDERS | H. LUNDBECK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |
| US-5112838-A | Treatment of schizophrenia | H. LUNDBECK A/S (DK) | 1992-05-12 | — | — | US | disclosed |
| EP-0470039-A2 | Novel 3-arylindole and 3-arylindazole derivatives | H. LUNDBECK A/S (DK) | 1992-02-05 | — | — | EP | disclosed |
| WO-1992000070-A1 | PIPERIDYL-SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 1992-01-09 | — | — | WO | disclosed |
| EP-0392959-A2 | Use of sertindole for the treatment of schizophrenia | H. LUNDBECK A/S (DK) | 1990-10-17 | — | — | EP | disclosed |