Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302767 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TP53HTTLMNA | |
| SCHEMBL28560557 | 0.86 | TP53 (0.55) | SMN1; SMN2ALDH1A1TP53HTTKDM4E | |
| SCHEMBL7298470 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1TP53HTTLMNA | |
| SCHEMBL7298114 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL7295840 | 0.78 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1TP53LMNAKDM4E | |
| SCHEMBL28575267 | 0.77 | MAPT (0.39) | SMN1; SMN2ALDH1A1TP53HTTLMNA | |
| SCHEMBL7299287 | 0.77 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL7302145 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL6578894 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TP53HTTKMT2A | |
| SCHEMBL6579151 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| CN-1060841-A | Quinazoline derivant and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-05-06 | — | — | CN | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |