Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306319 | 0.97 | HRH3 (0.33) | KCNH2IDO1HRH3MEN1KMT2A | |
| SCHEMBL7328315 | 0.89 | KCNH2 (0.30) | KCNH2MEN1KMT2A | |
| SCHEMBL7302023 | 0.86 | KCNH2 (0.30) | KCNH2 | |
| SCHEMBL27620642 | 0.81 | IDO1 (0.52) | IDO1HRH3MEN1KMT2ATDP1 | |
| SCHEMBL19786365 | 0.80 | SIGMAR1 (0.41) | KCNH2HRH3MEN1KMT2A | |
| SCHEMBL7297928 | 0.80 | ADRB2 (0.34) | — | |
| SCHEMBL19771037 | 0.80 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL3191931 | 0.79 | RAB9A (0.41) | KCNH2IDO1HRH3MEN1KMT2A | |
| SCHEMBL7299847 | 0.79 | MEN1 (0.33) | KCNH2IDO1HRH3MEN1KMT2A | |
| SCHEMBL27486126 | 0.78 | USP2 (0.45) | IDO1HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |