Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300154 | 0.85 | KMT2A (0.45) | PKMSRCMAPKAPK2ALKKDM4E | |
| SCHEMBL7297793 | 0.82 | BRD4 (0.44) | ALKKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7700541 | 0.77 | MAPT (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7296430 | 0.77 | HTT (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL7297004 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL21611522 | 0.75 | ALDH1A1 (0.46) | PKMSRCMAPKAPK2ALKMET | |
| SCHEMBL22588132 | 0.71 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL11628855 | 0.71 | SMN1; SMN2 (0.53) | KDM4EALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7305815 | 0.69 | PARP1 (0.42) | ALKMETALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9046374 | 0.68 | ALDH1A1 (0.50) | PKMMAPKAPK2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |