Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302858 | 0.85 | PKM (0.45) | KMT2AALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7297793 | 0.84 | BRD4 (0.44) | KMT2AABL1RIN1ALDH1A1HPGD | |
| SCHEMBL7296430 | 0.79 | HTT (0.40) | KMT2AALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL9046374 | 0.78 | ALDH1A1 (0.50) | KMT2AABL1RIN1ALDH1A1HPGD | |
| SCHEMBL7295195 | 0.73 | PARP1 (0.42) | KMT2AALDH1A1HPGDNPC1PDPK1 | |
| Hydrochloric Acid SCHEMBL21611611 | 0.72 | KMT2A (0.48) | KMT2AABL1RIN1ALDH1A1HPGD | |
| SCHEMBL7305815 | 0.70 | PARP1 (0.42) | ABL1ALDH1A1PDPK1RAB9ASMN1; SMN2 | |
| SCHEMBL22588460 | 0.68 | NPBWR1 (0.42) | KMT2AALDH1A1LTA4HMEN1 | |
| SCHEMBL15846544 | 0.67 | IP6K1 (0.59) | KMT2AABL1RIN1ALDH1A1HPGD | |
| SCHEMBL13946982 | 0.66 | ALDH1A1 (0.50) | KMT2AABL1RIN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |