SCHEMBL7302893

SCHEMBL7302893

COC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCC(=S)C1C(=O)CC1=Cc2cc(OC)ccc2C1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PREP P48147 1/20 0.37
DPP4 P27487 2/20 0.37
FKBP1A P62942 3/20 0.33
ALOX5 P09917 1/20 0.33
HSD11B1 P28845 1/20 0.33
PDK2 Q15119 1/20 0.33
ALDH1A1 P00352 3/20 0.33
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MTNR1B P49286 1/20 0.32
OPRM1 P35372 1/20 0.32
SLC8A1 P32418 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7302899 0.85 PREP (0.38) PREPDPP4FKBP1AALOX5ALDH1A1
SCHEMBL9048985 0.76 PREP (0.44) PREP
SCHEMBL7292862 0.74 PREP (0.47) PREP
SCHEMBL9050644 0.74 PREP (0.47) PREPPDK2SLC8A1
SCHEMBL7302438 0.73 MTNR1A (0.32) ALOX5
SCHEMBL9049755 0.73 PREP (0.43) PREP
SCHEMBL9050035 0.73 PREP (0.46) PREPDPP4
SCHEMBL7304730 0.73 PREP (0.53) PREPDPP4ALDH1A1OPRM1
SCHEMBL7303370 0.73 PREP (0.39) PREP
SCHEMBL9050376 0.72 PREP (0.44) PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed