Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.61 |
| ▸ | MMP2 | P08253 | 16/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 16/20 | 0.61 |
| ▸ | MMP1 | P03956 | 11/20 | 0.61 |
| ▸ | MMP9 | P14780 | 9/20 | 0.61 |
| ▸ | MMP14 | P50281 | 8/20 | 0.61 |
| ▸ | MMP3 | P08254 | 3/20 | 0.61 |
| ▸ | MMP7 | P09237 | 2/20 | 0.61 |
| ▸ | MMP8 | P22894 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | MMP10 | P09238 | 1/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305778 | 0.86 | MMP2 (0.59) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7309131 | 0.83 | MMP1 (0.39) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7301851 | 0.81 | MMP13 (0.73) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7307938 | 0.79 | MMP13 (0.70) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7303679 | 0.79 | MMP13 (0.67) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7310372 | 0.77 | MMP13 (0.76) | MMP13MMP2ADAM17MMP1MMP9 | |
| Cts-1027 SCHEMBL2381112 | 0.77 | MMP1 (1.00) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7142568 | 0.72 | MMP13 (0.52) | MMP13MMP2ADAM17MMP1MMP9 | |
| Hydrochloric Acid SCHEMBL7349688 | 0.71 | MMP13 (0.77) | MMP13MMP2ADAM17MMP1MMP9 | |
| SCHEMBL7141681 | 0.71 | MMP13 (0.52) | MMP13MMP2ADAM17MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |