Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478269 | 0.84 | MMP3 (0.57) | MMP3AOC3CA12CA2CA9 | |
| SCHEMBL7309475 | 0.82 | MMP3 (0.60) | MMP3AOC3TAAR1CA12CA1 | |
| SCHEMBL12133562 | 0.78 | MMP3 (0.55) | MMP3AOC3TAAR1CA1CA2 | |
| SCHEMBL6245112 | 0.78 | ALDH1A1 (0.42) | MMP3CA12CA1CA2CA9 | |
| SCHEMBL25477196 | 0.76 | TAAR1 (0.55) | MMP3AOC3TAAR1FDPSHDAC3 | |
| SCHEMBL1646282 | 0.76 | AOC3 (0.57) | MMP3AOC3TAAR1CA12CA1 | |
| SCHEMBL13184564 | 0.74 | TAAR1 (0.57) | MMP3AOC3TAAR1TSHRRCE1 | |
| SCHEMBL7082389 | 0.73 | MMP3 (0.50) | MMP3AOC3TAAR1CA12CA1 | |
| SCHEMBL6335172 | 0.73 | TAAR1 (0.55) | MMP3AOC3TAAR1HDAC3HDAC4 | |
| SCHEMBL7979490 | 0.73 | AOC3 (0.57) | AOC3TAAR1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |