Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23115547 | 0.79 | TLR8 (0.65) | — | |
| SCHEMBL23115488 | 0.79 | TLR8 (0.70) | — | |
| SCHEMBL345944 | 0.77 | NPC1 (0.51) | ALDH1A1HPGDKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL12964716 | 0.77 | KDM4E (0.83) | ALDH1A1MAPK1HPGDKDM4ENPC1 | |
| SCHEMBL3621429 | 0.75 | NOTUM (0.56) | ALDH1A1MAPK1HPGDKDM4ENPC1 | |
| SCHEMBL7310699 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MAPK1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7312332 | 0.74 | RAB9A (0.41) | ALDH1A1HPGDKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL12626897 | 0.74 | NPC1 (0.84) | ALDH1A1MAPK1HPGDKDM4ENPC1 | |
| SCHEMBL2750427 | 0.73 | ALDH1A1 (0.51) | ALDH1A1MAPK1HPGDKDM4ENPC1 | |
| SCHEMBL3613332 | 0.71 | ALDH1A1 (0.46) | ALDH1A1MAPK1HPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |