Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621429 | 0.83 | NOTUM (0.56) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL345944 | 0.81 | NPC1 (0.51) | RAB9AKMT2ASMN1; SMN2NPC1MAPT | |
| SCHEMBL9637871 | 0.74 | ALDH1A1 (0.59) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7303064 | 0.74 | ALDH1A1 (0.55) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7310699 | 0.71 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2753803 | 0.70 | CYP1A1 (0.44) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2954516 | 0.67 | ALDH1A1 (0.79) | CYP1B1CYP1A1ALDH1A1CYP1A2CYP2E1 | |
| SCHEMBL7223282 | 0.67 | NPC1 (0.47) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2750754 | 0.67 | CYP1B1 (0.46) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2750255 | 0.67 | RAB9A (0.41) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | claimed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |