Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | PROC | P04070 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300905 | 0.91 | MME (0.64) | MMEMMP8PROC | |
| SCHEMBL7294378 | 0.85 | MME (0.56) | MMEPROC | |
| SCHEMBL7291761 | 0.84 | MME (0.39) | MMEACE | |
| SCHEMBL7302752 | 0.83 | ACE (0.38) | MMEACE | |
| SCHEMBL7294105 | 0.81 | MME (0.82) | MMEMMP8 | |
| SCHEMBL7295035 | 0.80 | ERCC1 (0.46) | MMP8 | |
| SCHEMBL7295024 | 0.77 | KMT2A (0.48) | MME | |
| SCHEMBL7359978 | 0.76 | MME (0.41) | MMEMMP8ACE | |
| SCHEMBL7294394 | 0.75 | MME (0.63) | MMEMMP8PROC | |
| SCHEMBL7301481 | 0.75 | TOP1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |