Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.56 |
| ▸ | PROC | P04070 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294394 | 0.92 | MME (0.63) | MMEPROCMEN1KMT2ANPC1 | |
| SCHEMBL7303622 | 0.89 | MME (0.43) | MMEMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7295886 | 0.85 | HTR2C (0.40) | MME | |
| SCHEMBL7303084 | 0.85 | MME (0.57) | MMEPROC | |
| SCHEMBL7297983 | 0.84 | MME (0.36) | MMEMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7294424 | 0.82 | MME (0.40) | MME | |
| SCHEMBL7294410 | 0.81 | GHSR (0.36) | MMEMEN1KMT2A | |
| SCHEMBL7294105 | 0.80 | MME (0.82) | MME | |
| SCHEMBL7294514 | 0.80 | TSHR (0.41) | — | |
| SCHEMBL7291810 | 0.78 | MME (0.42) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516980-B1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMA INC (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5252601-A | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0516980-A1 | Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-09 | — | — | EP | disclosed |