Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301268 | 0.77 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7313228 | 0.77 | CNR1 (0.47) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7312082 | 0.74 | SMN1; SMN2 (0.43) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7305504 | 0.72 | PKM (0.49) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7305589 | 0.72 | SMN1; SMN2 (0.44) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL3300806 | 0.71 | TSHR (0.75) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7314488 | 0.69 | TSHR (0.55) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL1855017 | 0.68 | KMT2A (0.51) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL13286855 | 0.68 | SMN1; SMN2 (0.57) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL7309950 | 0.68 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |