Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314488 | 0.79 | TSHR (0.55) | SMN1; SMN2TSHRPOLBALDH1A1PKM | |
| SCHEMBL7301268 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRPOLBALDH1A1MAPK1 | |
| SCHEMBL7308952 | 0.72 | TSHR (0.43) | SMN1; SMN2TSHRPOLBALDH1A1LMNA | |
| SCHEMBL7303376 | 0.72 | TSHR (0.48) | SMN1; SMN2TSHRPOLBALDH1A1CNR1 | |
| SCHEMBL2769910 | 0.68 | POLB (0.73) | SMN1; SMN2TSHRPOLBALDH1A1MAPK1 | |
| SCHEMBL7313228 | 0.68 | CNR1 (0.47) | SMN1; SMN2TSHRPOLBALDH1A1MAPK1 | |
| SCHEMBL7309950 | 0.68 | TSHR (0.57) | SMN1; SMN2TSHRPOLBALDH1A1MAPK1 | |
| SCHEMBL4578854 | 0.67 | CNR1 (0.66) | SMN1; SMN2TSHRALDH1A1CNR1PKM | |
| SCHEMBL29483599 | 0.67 | PKM (0.66) | SMN1; SMN2TSHRPOLBALDH1A1PKM | |
| SCHEMBL7305504 | 0.66 | PKM (0.49) | SMN1; SMN2TSHRPOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |