SCHEMBL7303377

SCHEMBL7303377

Nc1ccc2c(c1)C=C(CC(=O)C1CCN[C@H]1C(=O)N1CCCC1)C2

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PREP P48147 1/20 0.42
BRD4 O60885 1/20 0.32
ATAD2 Q6PL18 1/20 0.32
ADAM10 O14672 1/20 0.31
ERBB2 P04626 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7303370 0.81 PREP (0.39) PREP
SCHEMBL7437380 0.78 DPP4 (0.33) PREP
SCHEMBL7293165 0.77 PREP (0.40) PREPBRD4ATAD2ADAM10ERBB2
SCHEMBL7302899 0.72 PREP (0.38) PREP
SCHEMBL9050039 0.70 PREP (0.48) PREP
SCHEMBL9050399 0.69 PREP (0.46) PREP
SCHEMBL9791388 0.68 PREP (0.49) PREPADAM10ERBB2
SCHEMBL7303343 0.67 PREP (0.56) PREP
SCHEMBL7296377 0.67 DPP4 (0.42) PREP
SCHEMBL7302998 0.67 DPP4 (0.42) PREPADAM10ERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed