SCHEMBL7303393

SCHEMBL7303393

CN1CC[C@@H](c2ccc(F)cc2)[C@H](CN2C(=O)c3ccccc3C2=O)C1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.49
SLC6A3 Q01959 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7303385 1.00 ACHE (0.49) ACHESLC6A3
SCHEMBL7316702 0.84 SLC6A3 (0.46) SLC6A3
SCHEMBL7316694 0.84 SLC6A3 (0.46) SLC6A3
SCHEMBL16544595 0.81 CYP1A2 (0.45)
SCHEMBL14697185 0.79 SLC6A2 (0.49) SLC6A3
SCHEMBL14697184 0.79 SLC6A2 (0.49) SLC6A3
SCHEMBL16423080 0.77 MMP2 (0.44)
SCHEMBL16423078 0.77 MMP2 (0.44)
SCHEMBL16423081 0.77 MMP2 (0.44)
SCHEMBL20348865 0.76 SLC6A3 (0.57) SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0639568-A1 Piperidine compounds, their preparation and use in the treatment of neurodegenerative disorders NOVO NORDISK A/S (DK) 1995-02-22 EP claimed
EP-0639568-A1 Piperidine compounds, their preparation and use in the treatment of neurodegenerative disorders NOVO NORDISK A/S (DK) 1995-02-22 EP disclosed